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pentobarbital will lessen the level or outcome of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.overall health centers / rest center/nembutal pentobarbital sodium posting